NEWS

Polynucleotides

Polynucleotides, derived from purified salmon DNA, are a relatively new entrant in aesthetic and regenerative medicine. These substances have shown promising results in skin rejuvenation and collagen stimulation. Here's an in-depth look at how polynucleotides stimulate collagen production and their benefits:

How Polynucleotides Stimulate Collagen Production

1. Cellular Regeneration:
Polynucleotides (PN) are fragments of nucleic acids (DNA and RNA) that can penetrate the skin and enhance cellular regeneration. They act as biological stimulators, encouraging the repair and regeneration of tissues.

2. Activation of Fibroblasts:
Polynucleotides activate fibroblasts, the cells responsible for producing collagen and other extracellular matrix components. This activation leads to increased synthesis of collagen types I and III, essential for skin strength and elasticity.

3. Anti-Inflammatory Properties:
Polynucleotides possess anti-inflammatory properties that help reduce inflammation and promote a healthier skin environment, which is conducive to collagen production and tissue repair.

4. Hydration and Improved Extracellular Matrix:
Polynucleotides improve the skin's hydration and elasticity by enhancing the extracellular matrix's quality. A well-hydrated extracellular matrix provides an optimal environment for collagen synthesis and skin health.

Types of Collagen Stimulated by Polynucleotides

1. Type 1 Collagen:
This is the most abundant type of collagen found in the skin, making up about 80-90% of the dermal collagen. Type 1 collagen provides structural support, strength, and resilience to the skin.

2. Type 3 Collagen:
Often found alongside Type 1 collagen, Type 3 collagen is also essential for skin elasticity and firmness. It is particularly prevalent in younger skin and during the early stages of wound healing.

Benefits of Polynucleotides for Skin Rejuvenation

1. Enhanced Collagen Production:
Polynucleotides stimulate the production of collagen types I and III, leading to improved skin structure, strength, and elasticity.

2. Improved Skin Hydration:
By enhancing the extracellular matrix, polynucleotides improve skin hydration, which is crucial for maintaining a youthful appearance and preventing dryness and wrinkles.

3. Reduction of Fine Lines and Wrinkles:
The increased collagen production helps to plump up the skin, reducing the appearance of fine lines and wrinkles. The skin becomes firmer and more elastic over time.

4. Skin Repair and Regeneration:
Polynucleotides promote cellular repair and regeneration, which is beneficial for treating various skin concerns, including scars, pigmentation, and sun damage.

5. Anti-Inflammatory Effects:
The anti-inflammatory properties of polynucleotides help to calm and soothe the skin, reducing redness, irritation, and inflammation, which can enhance overall skin health and appearance.

Application and Usage

1. Injectable Treatments:
Polynucleotides are often administered via microinjections into the dermis. This method ensures that the active ingredients reach the deeper layers of the skin, where they can effectively stimulate collagen production and cellular regeneration.

2. Topical Formulations:
Polynucleotides can also be found in topical skincare products. While the penetration depth may be less than injectable treatments, they still provide benefits for skin hydration and surface rejuvenation.

3. Combination Therapies:
Polynucleotides can be combined with other treatments such as microneedling, PRP (platelet-rich plasma), and laser therapy to enhance overall results and stimulate collagen production more effectively.

Safety and Side Effects

1. Biocompatibility:
Polynucleotides are highly biocompatible, meaning they are well-tolerated by the body and have a low risk of adverse reactions.

2. Minimal Side Effects:
Common side effects are typically mild and may include temporary redness, swelling, or bruising at the injection site. These effects usually resolve within a few days.

Conclusion

Polynucleotides offer a promising approach to collagen stimulation and skin rejuvenation by promoting the production of types I and III collagen, improving skin hydration, and enhancing cellular regeneration. Their ability to activate fibroblasts and provide anti-inflammatory benefits makes them an effective option for improving skin texture, elasticity, and overall appearance. Incorporating polynucleotides into your aesthetic practice can provide patients with a cutting-edge solution for achieving healthier, more youthful skin.

Dr Giorgia Ratta Generation Aesthetics